Spontaneous resolution of a 13-mm Chiari malformation Type I in relation to differential growth of the posterior fossa volume.

Published

Journal Article

The case of a 3-year-old patient with tuberous sclerosis and a 13-mm Chiari malformation Type I that spontaneously disappeared over the course of 4 years is presented. Using morphometric measurements of the posterior fossa and cerebellum in this patient, the authors show that the volume of the posterior fossa at the time of initial evaluation was consistent with that reported as normal in the literature (180.24 cm3; normal volume 132-198 cm3). Moreover, the patient showed a normal rate of growth of his posterior fossa over the period of observation (201.05 cm3; normal range 153-230 cm3). Cerebellar volumes were found to increase only minimally during this time period, which is compatible with observations in healthy controls. The posterior fossa volume, on the other hand, was shown to increase significantly more than that of the cerebellum (p=0.0185). This differential growth may permit the tonsils to ascend back up into the posterior fossa. Therefore, pediatric patients with normal posterior fossa volumes and normal development may have a spontaneous resolution of their asymptomatic Chiari malformation Type I.

Full Text

Duke Authors

Cited Authors

  • Waldau, B; Domeshek, LF; Leigh, FA; Lum, KC; Fuchs, HE; Marcus, JR; Mukundan, S; Grant, GA

Published Date

  • February 2009

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 110 - 114

PubMed ID

  • 19278309

Pubmed Central ID

  • 19278309

Electronic International Standard Serial Number (EISSN)

  • 1933-0715

International Standard Serial Number (ISSN)

  • 1933-0707

Digital Object Identifier (DOI)

  • 10.3171/2008.10.peds08200

Language

  • eng