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High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.

Publication ,  Journal Article
Gururangan, S; McLaughlin, C; Quinn, J; Rich, J; Reardon, D; Halperin, EC; Herndon, J; Fuchs, H; George, T; Provenzale, J; Watral, M ...
Published in: J Clin Oncol
June 1, 2003

PURPOSE: We evaluated the usefulness of a treatment regimen that included high-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) in patients with newly diagnosed pineoblastoma (PBL). PATIENTS AND METHODS: Twelve patients with PBL were initially treated with surgery and induction chemotherapy. All but two patients underwent radiotherapy. Subsequently, all patients received HDC using cyclophosphamide (CTX) + melphalan (MEL) or busulfan (Bu) + MEL regimens and ASCR. RESULTS: A total of six children and six adults with median ages of 4.2 (range, 0.3 to 19.8 years) and 23 years (range, 23 to 43.7 years), respectively, were treated according to this strategy. Four patients had metastatic disease confined to the neuraxis. Five of 12 patients (42%) had a complete tumor resection at diagnosis. Ten patients received radiotherapy at median doses of 36.0 and 59.4 Gy to the neuraxis and pineal region, respectively. Eleven patients received HDC with CTX + MEL, and one patient received BU + MEL followed by ASCR. Nine patients are alive with no evidence of disease recurrence at a median of 62 months from diagnosis (range, 28 to 125 months), including three patients with metastatic disease and two infants who did not receive any radiotherapy. Three patients have died of progressive disease at 19, 32, and 37 months from diagnosis, respectively. The actuarial 4-year progression-free and overall survivals are 69% (95% confidence interval [CI], 39% to 99%) and 71% (95% CI, 43% to 99%), respectively. CONCLUSION: The use of HDC in addition to radiotherapy seems to be an effective treatment for patients with newly diagnosed pineoblastoma.

Duke Scholars

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

June 1, 2003

Volume

21

Issue

11

Start / End Page

2187 / 2191

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Survival Rate
  • Stem Cell Transplantation
  • Pinealoma
  • Pineal Gland
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Melphalan
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gururangan, S., McLaughlin, C., Quinn, J., Rich, J., Reardon, D., Halperin, E. C., … Martin, P. L. (2003). High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. J Clin Oncol, 21(11), 2187–2191. https://doi.org/10.1200/JCO.2003.10.096
Gururangan, Sridharan, Colleen McLaughlin, Jennifer Quinn, Jeremy Rich, David Reardon, Edward C. Halperin, James Herndon, et al. “High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.J Clin Oncol 21, no. 11 (June 1, 2003): 2187–91. https://doi.org/10.1200/JCO.2003.10.096.
Gururangan S, McLaughlin C, Quinn J, Rich J, Reardon D, Halperin EC, et al. High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. J Clin Oncol. 2003 Jun 1;21(11):2187–91.
Gururangan, Sridharan, et al. “High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.J Clin Oncol, vol. 21, no. 11, June 2003, pp. 2187–91. Pubmed, doi:10.1200/JCO.2003.10.096.
Gururangan S, McLaughlin C, Quinn J, Rich J, Reardon D, Halperin EC, Herndon J, Fuchs H, George T, Provenzale J, Watral M, McLendon RE, Friedman A, Friedman HS, Kurtzberg J, Vredenbergh J, Martin PL. High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas. J Clin Oncol. 2003 Jun 1;21(11):2187–2191.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

June 1, 2003

Volume

21

Issue

11

Start / End Page

2187 / 2191

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Survival Rate
  • Stem Cell Transplantation
  • Pinealoma
  • Pineal Gland
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Melphalan
  • Male