Skip to main content

Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.

Publication ,  Journal Article
Van Guilder, GP; Pretorius, M; Luther, JM; Byrd, JB; Hill, K; Gainer, JV; Brown, NJ
Published in: Hypertension
February 2008

To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1+9/-9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood flow and tissue-type plasminogen activator (t-PA) release in 89 normotensive, nonsmoking, white American subjects in whom degradation of bradykinin was blocked by enalaprilat. BE1 genotype frequencies were +9/+9:+9/-9:-9/-9=19:42:28. BE1 genotype was associated with systolic blood pressure (121.4+/-2.8, 113.8+/-1.8, and 110.6+/-1.8 mm Hg in +9/+9, +9/-9, and -9/-9 groups, respectively; P=0.007). In the absence of enalaprilat, bradykinin-stimulated forearm blood flow, forearm vascular resistance, and net t-PA release were similar among genotype groups. Enalaprilat increased basal forearm blood flow (P=0.002) and decreased basal forearm vascular resistance (P=0.01) without affecting blood pressure. Enalaprilat enhanced the effect of bradykinin on forearm blood flow, forearm vascular resistance, and t-PA release (all P<0.001). During enalaprilat, forearm blood flow was significantly lower and forearm vascular resistance was higher in response to bradykinin in the +9/+9 compared with +9/-9 and -9/-9 genotype groups (P=0.04 for both). t-PA release tended to be decreased in response to bradykinin in the +9/+9 group (P=0.08). When analyzed separately by gender, BE1 genotype was associated with bradykinin-stimulated t-PA release in angiotensin-converting enzyme inhibitor-treated men but not women (P=0.02 and P=0.77, respectively), after controlling for body mass index. There was no effect of BE1 genotype on responses to the bradykinin type 2 receptor-independent vasodilator methacholine during enalaprilat. In conclusion, the BDKRB2 BE1 polymorphism influences bradykinin type 2 receptor-mediated vasodilation during angiotensin-converting enzyme inhibition.

Duke Scholars

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

February 2008

Volume

51

Issue

2

Start / End Page

454 / 459

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Vascular Resistance
  • Tissue Plasminogen Activator
  • Sex Factors
  • Regional Blood Flow
  • Receptor, Bradykinin B2
  • Polymorphism, Genetic
  • Nitroprusside
  • Methacholine Chloride
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Van Guilder, G. P., Pretorius, M., Luther, J. M., Byrd, J. B., Hill, K., Gainer, J. V., & Brown, N. J. (2008). Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension, 51(2), 454–459. https://doi.org/10.1161/HYPERTENSIONAHA.107.102574
Van Guilder, Gary P., Mias Pretorius, James M. Luther, J Brian Byrd, Kevin Hill, James V. Gainer, and Nancy J. Brown. “Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.Hypertension 51, no. 2 (February 2008): 454–59. https://doi.org/10.1161/HYPERTENSIONAHA.107.102574.
Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, et al. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension. 2008 Feb;51(2):454–9.
Van Guilder, Gary P., et al. “Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.Hypertension, vol. 51, no. 2, Feb. 2008, pp. 454–59. Pubmed, doi:10.1161/HYPERTENSIONAHA.107.102574.
Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension. 2008 Feb;51(2):454–459.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

February 2008

Volume

51

Issue

2

Start / End Page

454 / 459

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Vascular Resistance
  • Tissue Plasminogen Activator
  • Sex Factors
  • Regional Blood Flow
  • Receptor, Bradykinin B2
  • Polymorphism, Genetic
  • Nitroprusside
  • Methacholine Chloride