Two-faced cyclins with eyes on the targets

Journal Article

We recently reported that the 'hydrophobic patch' (HP) of the Saccharomyces cerevisiae S-phase cyclin Clb5 facilitates its interaction with Orco (via its Cy or RXL motif), providing a mechanism that helps prevent rereplication from individual origins. This is the first finding of a biological function for an interaction between a cyclin and a cyclin-binding motif (Cy or RXL motif) in a target protein in Saccharomyces cerevisiae. It is also the first such example involving a B-type cyclin in any organism. Yet, some of our observations as well as work from other groups suggest that HP-RXL interactions are functionally important for cyclin-Cdk signaling to other targets. The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions. ©2005 Landes Bioscience.

Duke Authors

Cited Authors

  • Archambault, V; Buchler, NE; Wilmes, GM; Jacobson, MD; Cross, FR

Published Date

  • 2005

Published In

  • Cell Cycle

Volume / Issue

  • 4 / 1

Start / End Page

  • 125 - 130

PubMed ID

  • 15611618