Differentiation of benign from malignant pulmonary nodules with digitized chest radiographs.

Journal Article (Journal Article)

To assess whether it is possible to distinguish benign from malignant solitary pulmonary nodules with digital techniques, a retrospective study of 68 patients with proved solitary nodules was performed. The conventional chest radiograph for each patient was digitized to 2,048 X 2,048 X 12 bits, and changes in the optical density within the nodule were analyzed. A number (the corrected gradient number) was then generated that reflected this variation. Striking differences were noted between 26 malignant nodules and 21 calcified granulomas. The technique was then applied to 21 benign nodules that had initially required thoracotomy or further study for diagnosis. In nine of these 21 patients (43%), the corrected gradient number allowed correct classification as a benign lesion.

Full Text

Duke Authors

Cited Authors

  • Sherrier, RH; Chiles, C; Johnson, GA; Ravin, CE

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 162 / 3

Start / End Page

  • 645 - 649

PubMed ID

  • 3809476

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.162.3.3809476


  • eng

Conference Location

  • United States