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Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.

Publication ,  Journal Article
Badea, CT; Wetzel, AW; Mistry, N; Pomerantz, S; Nave, D; Johnson, GA
Published in: Comput Med Imaging Graph
April 2008

Micro-CT-based cardiac function estimation in small animals requires measurement of left ventricle (LV) volume at multiple time points during the cardiac cycle. Measurement accuracy depends on the image resolution, its signal and noise properties, and the analysis procedure. This work compares the accuracy of the Otsu thresholding and a region sampled binary mixture approach, for live mouse LV volume measurement using 100 microm resolution datasets. We evaluate both analysis methods after varying the volume of injected contrast agent and the number of projections used for CT reconstruction with a goal of permitting reduced levels of both X-ray and contrast agent doses.

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Published In

Comput Med Imaging Graph

DOI

ISSN

0895-6111

Publication Date

April 2008

Volume

32

Issue

3

Start / End Page

239 / 250

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred C57BL
  • Mice
  • Imaging, Three-Dimensional
  • Heart Ventricles
  • Contrast Media
  • Animals
 

Citation

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Badea, C. T., Wetzel, A. W., Mistry, N., Pomerantz, S., Nave, D., & Johnson, G. A. (2008). Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent. Comput Med Imaging Graph, 32(3), 239–250. https://doi.org/10.1016/j.compmedimag.2007.12.004
Badea, Cristian T., Arthur W. Wetzel, Nilesh Mistry, Stuart Pomerantz, Demian Nave, and G Allan Johnson. “Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.Comput Med Imaging Graph 32, no. 3 (April 2008): 239–50. https://doi.org/10.1016/j.compmedimag.2007.12.004.
Badea CT, Wetzel AW, Mistry N, Pomerantz S, Nave D, Johnson GA. Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent. Comput Med Imaging Graph. 2008 Apr;32(3):239–50.
Badea, Cristian T., et al. “Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.Comput Med Imaging Graph, vol. 32, no. 3, Apr. 2008, pp. 239–50. Pubmed, doi:10.1016/j.compmedimag.2007.12.004.
Badea CT, Wetzel AW, Mistry N, Pomerantz S, Nave D, Johnson GA. Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent. Comput Med Imaging Graph. 2008 Apr;32(3):239–250.
Journal cover image

Published In

Comput Med Imaging Graph

DOI

ISSN

0895-6111

Publication Date

April 2008

Volume

32

Issue

3

Start / End Page

239 / 250

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Mice, Inbred C57BL
  • Mice
  • Imaging, Three-Dimensional
  • Heart Ventricles
  • Contrast Media
  • Animals