Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.
Journal Article (Journal Article)
Micro-CT-based cardiac function estimation in small animals requires measurement of left ventricle (LV) volume at multiple time points during the cardiac cycle. Measurement accuracy depends on the image resolution, its signal and noise properties, and the analysis procedure. This work compares the accuracy of the Otsu thresholding and a region sampled binary mixture approach, for live mouse LV volume measurement using 100 microm resolution datasets. We evaluate both analysis methods after varying the volume of injected contrast agent and the number of projections used for CT reconstruction with a goal of permitting reduced levels of both X-ray and contrast agent doses.
Full Text
Duke Authors
Cited Authors
- Badea, CT; Wetzel, AW; Mistry, N; Pomerantz, S; Nave, D; Johnson, GA
Published Date
- April 2008
Published In
Volume / Issue
- 32 / 3
Start / End Page
- 239 - 250
PubMed ID
- 18243656
Pubmed Central ID
- PMC2276250
International Standard Serial Number (ISSN)
- 0895-6111
Digital Object Identifier (DOI)
- 10.1016/j.compmedimag.2007.12.004
Language
- eng
Conference Location
- United States