Function of tau protein in adult newborn neurons.

Published

Journal Article

Levels of tau phosphorylation are high during the developmental period of intense neurite outgrowth, but decrease later. We here investigated whether tau protein plays a role in adult neurogenesis. First we demonstrate that new neurons generated in the subgranular zone express tau in a hyperphosphorylated form. Phospho-tau expression colocalized with doublecortin but not with glial fibrillary acidic protein, Ki67 or calbindin. The same was observed in the subventricular zone. Tau knockout mice did not show a significant decrease in the number of doublecortin-positive cells, although a deficit in migration was observed. These findings suggest that basal tau phosphorylation present in adult animals is in part due to neurogenesis, and from Tau knockout mice it seems that tau is involved in normal migration of new neurons.

Full Text

Duke Authors

Cited Authors

  • Fuster-Matanzo, A; de Barreda, EG; Dawson, HN; Vitek, MP; Avila, J; Hernández, F

Published Date

  • September 17, 2009

Published In

Volume / Issue

  • 583 / 18

Start / End Page

  • 3063 - 3068

PubMed ID

  • 19695252

Pubmed Central ID

  • 19695252

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2009.08.017

Language

  • eng

Conference Location

  • England