Mixed connective tissue disease with arterial thrombosis, antiphospholipid antibodies and heparin induced thrombocytopenia.
Journal Article
We report a patient with mixed connective tissue disease (MCTD) who presented with thrombosis of the right femoral artery in association with antiphospholipid antibodies (aPL). When treated surgically and with heparin prophylaxis, she developed heparin induced thrombocytopenia and thrombosis which necessitated amputation of a lower limb. Thus our patient developed 2 separate groups of autoantibodies associated with thrombotic events. Our case highlights an association between thrombosis, aPL and MCTD. Furthermore, it emphasizes a need for intensive monitoring when hypercoaguable individuals with connective tissue disorders are treated with heparin.
Full Text
Duke Authors
Cited Authors
- Jackson, J; McDonald, M; Casey, E; Kelleher, S; Murray, A; Temperley, I; Shanik, G; Feighery, C; Jackson, F
Published Date
- November 1990
Published In
Volume / Issue
- 17 / 11
Start / End Page
- 1523 - 1524
PubMed ID
- 2273496
Pubmed Central ID
- 2273496
International Standard Serial Number (ISSN)
- 0315-162X
Language
- eng
Conference Location
- Canada