Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo.

Published

Journal Article

BACKGROUND: In vivo experimentation is the most realistic approach for exploring the vascular biological response to the hemodynamic stresses that are present in life. Post-mortem vascular casting has been used to define the in vivo geometry for hemodynamic simulation; however, this procedure damages or destroys the tissue and cells on which biological assays are to be performed. METHOD OF APPROACH: Two statistical approaches, regional (RSH) and linear (LSH) statistical hemodynamics, are proposed and illustrated, in which flow simulations from one series of experiments are used to define a best estimate of the hemodynamic environment in a second series. As an illustration of the technique, RSH is used to compare the gene expression profiles of regions of the proximal external iliac arteries of swine exposed to different levels of time-average shear stress. RESULTS: The results indicate that higher shears promote a more atheroprotective expression phenotype in porcine arterial endothelium. CONCLUSION: Statistical hemodynamics provides a realistic estimate of the hemodynamic stress on vascular tissue that can be correlated against biological response.

Full Text

Duke Authors

Cited Authors

  • Friedman, MH; Himburg, HA; LaMack, JA

Published Date

  • December 2006

Published In

Volume / Issue

  • 128 / 6

Start / End Page

  • 965 - 968

PubMed ID

  • 17154699

Pubmed Central ID

  • 17154699

Electronic International Standard Serial Number (EISSN)

  • 1528-8951

International Standard Serial Number (ISSN)

  • 0148-0731

Digital Object Identifier (DOI)

  • 10.1115/1.2354212

Language

  • eng