Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo.
Journal Article (Journal Article)
Background
In vivo experimentation is the most realistic approach for exploring the vascular biological response to the hemodynamic stresses that are present in life. Post-mortem vascular casting has been used to define the in vivo geometry for hemodynamic simulation; however, this procedure damages or destroys the tissue and cells on which biological assays are to be performed.Method of approach
Two statistical approaches, regional (RSH) and linear (LSH) statistical hemodynamics, are proposed and illustrated, in which flow simulations from one series of experiments are used to define a best estimate of the hemodynamic environment in a second series. As an illustration of the technique, RSH is used to compare the gene expression profiles of regions of the proximal external iliac arteries of swine exposed to different levels of time-average shear stress.Results
The results indicate that higher shears promote a more atheroprotective expression phenotype in porcine arterial endothelium.Conclusion
Statistical hemodynamics provides a realistic estimate of the hemodynamic stress on vascular tissue that can be correlated against biological response.Full Text
Duke Authors
Cited Authors
- Friedman, MH; Himburg, HA; LaMack, JA
Published Date
- December 2006
Published In
Volume / Issue
- 128 / 6
Start / End Page
- 965 - 968
PubMed ID
- 17154699
Electronic International Standard Serial Number (EISSN)
- 1528-8951
International Standard Serial Number (ISSN)
- 0148-0731
Digital Object Identifier (DOI)
- 10.1115/1.2354212
Language
- eng