An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration.
Journal Academic Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
This study evaluated whether the aggregation behavior of a thermally responsive elastin-like polypeptide (ELP) prolongs protein residence time at the dorsal root ganglion (DRG). This work involves development of a sustained-release drug delivery vehicle to provide high and sustained levels of biologic therapeutics to the dorsal root ganglion while minimizing systemic exposure.
Shamji, MF; Whitlatch, L; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA
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