An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration.

This study evaluated whether the aggregation behavior of a thermally responsive elastin-like polypeptide (ELP) prolongs protein residence time at the dorsal root ganglion (DRG). This work involves development of a sustained-release drug delivery vehicle to provide high and sustained levels of biologic therapeutics to the dorsal root ganglion while minimizing systemic exposure.

Full Text

Duke Authors

Cited Authors

  • Shamji, MF; Whitlatch, L; Friedman, AH; Richardson, WJ; Chilkoti, A; Setton, LA

Published Date

  • April 2008

Published In

Volume / Issue

  • 33 / 7

Start / End Page

  • 748 - 754

PubMed ID

  • 18379401

Electronic International Standard Serial Number (EISSN)

  • 1528-1159

Digital Object Identifier (DOI)

  • 10.1097/BRS.0b013e3181695773


  • eng

Citation Source

  • PubMed