Real-time 3D contrast-enhanced transcranial ultrasound

Journal Article

Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real-time 3D contrast-enhanced transcranial ultrasound with phase aberration correction. Using real-time 3D (RT3D) ultrasound and micro-bubble contrast agent, we scanned 17 healthy volunteers via a single temporal window and 9 via the sub-occipital window and report our detection rates for the major cerebral vessels. In 82% of subjects, we identified the ipsilateral circle of Willis from the temporal window, and in 65% we imaged the entire circle of Willis. From the sub-occipital window, we detected the entire vertebrobasilar circulation in 22% of subjects, and in 50% the basilar artery. After performing phase aberration correction on one subject, we were able to increase the diagnostic value of the scan, detecting a vessel not present in the uncorrected scan. These preliminary results suggest that RT3D CE transcranial US with phase aberration correction has the potential to greatly impact the field of neurosonology. ©2007 IEEE.

Full Text

Duke Authors

Cited Authors

  • Ivancevich, NM; Pinton, GF; Smith, SW; Nicoletto, HA; Seism, M; Bennett, E; Laskowitz, DT

Published Date

  • 2007

Published In

Start / End Page

  • 550 - 553

International Standard Serial Number (ISSN)

  • 1051-0117

Digital Object Identifier (DOI)

  • 10.1109/ULTSYM.2007.143