Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes

Journal Article (Academic article)

We have demonstrated for the first time the feasibility of multiplex detection using the surface-enhanced Raman scattering-based molecular sentinel ( MS) technology in a homogeneous solution. Two MS nanoprobes tagged with different Raman labels were used to detect the presence of the erbB-2 and ki-67 breast cancer biomarkers. The multiplexing capability of the MS technique was demonstrated by mixing the two MS nanoprobes and tested in the presence of single or multiple DNA targets.

Full Text

Duke Authors

Cited Authors

  • Wang, HN; Vo dinh, T

Published Date

  • February 2009

Published In

Volume / Issue

  • 20 / 6

PubMed ID

  • 19417369

Pubmed Central ID

  • PMC4022306

International Standard Serial Number (ISSN)

  • 0957-4484