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Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes

Publication ,  Journal Article
Wang, HN; Vo dinh, T
Published in: Nanotechnology
February 2009

We have demonstrated for the first time the feasibility of multiplex detection using the surface-enhanced Raman scattering-based molecular sentinel ( MS) technology in a homogeneous solution. Two MS nanoprobes tagged with different Raman labels were used to detect the presence of the erbB-2 and ki-67 breast cancer biomarkers. The multiplexing capability of the MS technique was demonstrated by mixing the two MS nanoprobes and tested in the presence of single or multiple DNA targets.

Duke Scholars

Published In

Nanotechnology

ISSN

0957-4484

Publication Date

February 2009

Volume

20

Issue

6

Related Subject Headings

  • Spectrum Analysis, Raman
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Nucleic Acid Hybridization
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Ki-67 Antigen
  • Humans
  • Clinical Laboratory Techniques
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, H. N., and T. Vo dinh. “Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes.” Nanotechnology 20, no. 6 (February 2009).
Wang, H. N., and T. Vo dinh. “Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes.” Nanotechnology, vol. 20, no. 6, Feb. 2009.
Journal cover image

Published In

Nanotechnology

ISSN

0957-4484

Publication Date

February 2009

Volume

20

Issue

6

Related Subject Headings

  • Spectrum Analysis, Raman
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Nucleic Acid Hybridization
  • Nanotechnology
  • Nanoscience & Nanotechnology
  • Ki-67 Antigen
  • Humans
  • Clinical Laboratory Techniques
  • Breast Neoplasms