Imaging the distribution of magnetic nanoparticles with ultrasound.

Published

Journal Article

Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage in a nearby pickup coil. In this way, focused ultrasound can be used to map, or image, the spatial distribution of the magnetic particles after these particles have been introduced into the body. The magnetic particles could be antibody-labeled to target tumor cells or used as a cardiovascular contrast agent, among other applications. The magnitude of the induced signal is estimated for one micron particles with a Fe/tissue volume fraction of 10(-6), which is about the limit of detectability for MRI superparamagnetic contrast agents consisting of single domain iron-oxide particles. One advantage of this method compared to conventional MRI is potentially greater sensitivity due to the absence of a large background signal.

Full Text

Duke Authors

Cited Authors

  • Norton, SJ; Vo-Dinh, T

Published Date

  • May 2007

Published In

Volume / Issue

  • 26 / 5

Start / End Page

  • 660 - 665

PubMed ID

  • 17518060

Pubmed Central ID

  • 17518060

Electronic International Standard Serial Number (EISSN)

  • 1558-254X

International Standard Serial Number (ISSN)

  • 0278-0062

Digital Object Identifier (DOI)

  • 10.1109/tmi.2007.895476

Language

  • eng