Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection.
Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
Hunter, M; Backman, V; Popescu, G; Kalashnikov, M; Boone, CW; Wax, A; Gopal, V; Badizadegan, K; Stoner, GD; Feld, MS
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