Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection.
Journal Article (Journal Article)
Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
- Hunter, M; Backman, V; Popescu, G; Kalashnikov, M; Boone, CW; Wax, A; Gopal, V; Badizadegan, K; Stoner, GD; Feld, MS
- September 2006
Volume / Issue
- 97 / 13
Start / End Page
- 138102 -
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)