Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection.

Journal Article (Journal Article)

Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.

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Duke Authors

Wax, Adam P.

Cited Authors

Hunter, M; Backman, V; Popescu, G; Kalashnikov, M; Boone, CW; Wax, A; Gopal, V; Badizadegan, K; Stoner, GD; Feld, MS

Published Date

September 2006

Published In

Physical Review Letters

Volume / Issue

97 / 13

Start / End Page

138102 -

PubMed ID

17026078

Electronic International Standard Serial Number (EISSN)

1079-7114

International Standard Serial Number (ISSN)

0031-9007

Digital Object Identifier (DOI)

10.1103/physrevlett.97.138102

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