Multiplexed low coherence interferometry instrument for measuring microbicide gel thickness distribution.

Journal Article (Journal Article)

We present a Fourier-domain, multiplexed low coherence interferometry (LCI) instrument designed for application to intravaginal measurement of microbicidal gel distribution. Microbicide gels are topical products developed to combat sexually transmitted diseases, such as HIV/AIDS, by acting as delivery vehicles for active drugs and barrier layers to vaginal tissue. Measuring microbicide gel vaginal distribution is key to understanding the gel's biological effectiveness. This study presents a new LCI system for measuring gel distribution that uses six multiplexed channels to achieve broad area scanning without the need for a mechanical scanner. The presented results characterize the performance of the Fourier-domain multiplexed LCI system in measuring gel thickness distribution. The system demonstrates good optical signal-to-noise ratio, steady performance across all channels, negligible cross talk, and accurate measurement with micrometer scale resolution. The potential impact of using a multiplexed LCI system for in vivo measurements is also discussed.

Full Text

Duke Authors

Cited Authors

  • Drake, TK; Robles, FE; Wax, A

Published Date

  • April 2009

Published In

Volume / Issue

  • 48 / 10

Start / End Page

  • D14 - D19

PubMed ID

  • 19340102

Electronic International Standard Serial Number (EISSN)

  • 1539-4522

International Standard Serial Number (ISSN)

  • 1559-128X

Digital Object Identifier (DOI)

  • 10.1364/ao.48.000d14


  • eng