Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors.

Journal Article (Journal Article)

One goal of recent research on plasmonic nanoparticle-based sensors is maximizing nanoparticle sensitivity or shift of resonance peak wavelength per refractive index change. Equally important is a measurement system's peak location uncertainty or shift resolution. We provide systematic analyses and discuss optimization of factors that determine peak location uncertainty, reporting values as low as 0.3 nm for the presented scheme. This type of analysis is important, in part, because it provides a means of evaluating detection thresholds for biosensor applications such as analyte binding. We estimate thresholds of 310 streptavidin molecules for the presented scheme and 20 molecules with system improvements.

Full Text

Duke Authors

Cited Authors

  • Curry, A; Nusz, G; Chilkoti, A; Wax, A

Published Date

  • April 2007

Published In

Volume / Issue

  • 46 / 10

Start / End Page

  • 1931 - 1939

PubMed ID

  • 17356640

Electronic International Standard Serial Number (EISSN)

  • 1539-4522

International Standard Serial Number (ISSN)

  • 1559-128X

Digital Object Identifier (DOI)

  • 10.1364/ao.46.001931


  • eng