In vitro assay for curative activity in blood of mice infected with Trypanosoma musculi.


Journal Article

An in vitro assay for curative antibody present in plasma of mice cured of Trypanosoma musculi is described. The assay involves the addition of plasma to a sample of infected blood, followed by hourly monitoring of the parasite count therein. Immune plasma effected a significant reduction in parasite number, whereas normal mouse plasma did not. Heat treatment of immune plasma for 30 min at 56 degrees C abolished its ability to effect any reduction. The assay is simple, rapid, and economical and correlates well with results of all in vivo studies performed to date.

Full Text

Cited Authors

  • Wechsler, DS; Kongshavn, PA

Published Date

  • August 1, 1986

Published In

Volume / Issue

  • 53 / 2

Start / End Page

  • 240 - 244

PubMed ID

  • 3733217

Pubmed Central ID

  • 3733217

Electronic International Standard Serial Number (EISSN)

  • 1098-5522

International Standard Serial Number (ISSN)

  • 0019-9567


  • eng