Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis.

Published

Journal Article (Review)

Systemic infections in premature and term infants cause significant morbidity and mortality in spite of appropriate antimicrobial therapy. Consequently, immunotherapy has emerged as a potential adjuvant therapeutic modality to reduce the incidence and mortality associated with neonatal sepsis.The most recent findings during the review period include systematic reviews of previously published trials evaluating the use of intravenous immunoglobulin and colony-stimulating factors in neonatal sepsis. In addition, the most recent trials describing the use of antistaphylococcal antibodies, probiotics, glutamine supplementation, recombinant human protein C, and lactoferrin in the prevention and treatment of neonatal sepsis have been reviewed.Immunotherapy used as an adjuvant for the prevention and treatment of neonatal sepsis holds promise. Clinical trials specifically designed toward the neonatal population and appropriately powered to detect treatment differences are necessary prior to universal recommendation of these therapies in the nursery.

Full Text

Duke Authors

Cited Authors

  • Cohen-Wolkowiez, M; Benjamin, DK; Capparelli, E

Published Date

  • April 2009

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 177 - 181

PubMed ID

  • 19276977

Pubmed Central ID

  • 19276977

Electronic International Standard Serial Number (EISSN)

  • 1531-698X

International Standard Serial Number (ISSN)

  • 1040-8703

Digital Object Identifier (DOI)

  • 10.1097/MOP.0b013e32832925e5

Language

  • eng