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Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis.

Publication ,  Journal Article
Cohen-Wolkowiez, M; Benjamin, DK; Capparelli, E
Published in: Curr Opin Pediatr
April 2009

PURPOSE OF REVIEW: Systemic infections in premature and term infants cause significant morbidity and mortality in spite of appropriate antimicrobial therapy. Consequently, immunotherapy has emerged as a potential adjuvant therapeutic modality to reduce the incidence and mortality associated with neonatal sepsis. RECENT FINDINGS: The most recent findings during the review period include systematic reviews of previously published trials evaluating the use of intravenous immunoglobulin and colony-stimulating factors in neonatal sepsis. In addition, the most recent trials describing the use of antistaphylococcal antibodies, probiotics, glutamine supplementation, recombinant human protein C, and lactoferrin in the prevention and treatment of neonatal sepsis have been reviewed. SUMMARY: Immunotherapy used as an adjuvant for the prevention and treatment of neonatal sepsis holds promise. Clinical trials specifically designed toward the neonatal population and appropriately powered to detect treatment differences are necessary prior to universal recommendation of these therapies in the nursery.

Duke Scholars

Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

April 2009

Volume

21

Issue

2

Start / End Page

177 / 181

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sepsis
  • Recombinant Proteins
  • Protein C
  • Probiotics
  • Pediatrics
  • Lactoferrin
  • Infant, Premature, Diseases
  • Infant, Newborn, Diseases
  • Infant, Newborn
 

Citation

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Cohen-Wolkowiez, M., Benjamin, D. K., & Capparelli, E. (2009). Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr, 21(2), 177–181. https://doi.org/10.1097/MOP.0b013e32832925e5
Cohen-Wolkowiez, Michael, Daniel K. Benjamin, and Edmund Capparelli. “Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis.Curr Opin Pediatr 21, no. 2 (April 2009): 177–81. https://doi.org/10.1097/MOP.0b013e32832925e5.
Cohen-Wolkowiez M, Benjamin DK, Capparelli E. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr. 2009 Apr;21(2):177–81.
Cohen-Wolkowiez, Michael, et al. “Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis.Curr Opin Pediatr, vol. 21, no. 2, Apr. 2009, pp. 177–81. Pubmed, doi:10.1097/MOP.0b013e32832925e5.
Cohen-Wolkowiez M, Benjamin DK, Capparelli E. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr. 2009 Apr;21(2):177–181.

Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

April 2009

Volume

21

Issue

2

Start / End Page

177 / 181

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sepsis
  • Recombinant Proteins
  • Protein C
  • Probiotics
  • Pediatrics
  • Lactoferrin
  • Infant, Premature, Diseases
  • Infant, Newborn, Diseases
  • Infant, Newborn