The matrix stick-breaking process: Flexible Bayes meta-analysis

Journal Article (Journal Article)

In analyzing data from multiple related studies, it often is of interest to borrow information across studies and to cluster similar studies. Although parametric hierarchical models are commonly used, of concern is sensitivity to the form chosen for the random-effects distribution. A Dirichlet process (DP) prior can allow the distribution to be unknown, while clustering studies; however, the DP does not allow local clustering of studies with respect to a subset of the coefficients without making independence assumptions. Motivated by this problem, we propose a matrix stick-breaking process (MSBP) as a prior for a matrix of random probability measures. Properties of the MSBP are considered, and methods are developed for posterior computation using Markov chain Monte Carlo. Using the MSBP as a prior for a matrix of study-specific regression coefficients, we demonstrate advantages over parametric modeling in simulated examples. The methods are further illustrated using a multinational uterotrophic bioassay study.

Full Text

Duke Authors

Cited Authors

  • Dunson, DB; Xue, Y; Carin, L

Published Date

  • March 1, 2008

Published In

Volume / Issue

  • 103 / 481

Start / End Page

  • 317 - 327

International Standard Serial Number (ISSN)

  • 0162-1459

Digital Object Identifier (DOI)

  • 10.1198/016214507000001364

Citation Source

  • Scopus