Role of epithelial nitric oxide in airway viral infection.


Journal Article (Review)

The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways.

Full Text

Cited Authors

  • Xu, W; Zheng, S; Dweik, RA; Erzurum, SC

Published Date

  • July 2006

Published In

Volume / Issue

  • 41 / 1

Start / End Page

  • 19 - 28

PubMed ID

  • 16781449

Pubmed Central ID

  • 16781449

Electronic International Standard Serial Number (EISSN)

  • 1873-4596

International Standard Serial Number (ISSN)

  • 0891-5849

Digital Object Identifier (DOI)

  • 10.1016/j.freeradbiomed.2006.01.037


  • eng