Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis.


Journal Article

Viral infection is the primary cause of respiratory morbidity in cystic fibrosis (CF) infants. Here, we identify that host factors allow increased virus replication and cytokine production, providing a mechanism for understanding the severity of virus disease in CF. Increased virus is due to lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in response to virus or IFNgamma. This can be attributed to impairment of activation of signal transducer and activator of transcription (STAT)1, a fundamental component to antiviral defense. NO donor or NOS2 overexpression provides protection from virus infection in CF, suggesting that NO is sufficient for antiviral host defense in the human airway and is one strategy for antiviral therapy in CF children.

Full Text

Cited Authors

  • Zheng, S; De, BP; Choudhary, S; Comhair, SAA; Goggans, T; Slee, R; Williams, BRG; Pilewski, J; Haque, SJ; Erzurum, SC

Published Date

  • May 2003

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 619 - 630

PubMed ID

  • 12753739

Pubmed Central ID

  • 12753739

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(03)00114-6


  • eng