Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival.
Using a standardized laboratory rat model of burn wound sepsis, a regimen of once a day application of Silvadene has been found to be more effective treatment than Sulfamylon or cerium-Silvadene. Delaying treatment following infection resulted in decreased survival. Possible reasons for difference in mortality are once-daily application, or perhaps a change in sensitivity between drugs and the infective organism (Ps. aeruginosa) over time.
Salisbury, RE; Bevin, AG; Steinkraus, GE; Enterline, DS
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