Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.

Published

Journal Article

BACKGROUND: Vitamin A (retinol), in the form of retinoic acid (RA), is essential for normal development of the human embryo. Studies in the mouse and zebrafish have shown that retinol is metabolized in the developing spinal cord and must be maintained in a precise balance along the anteroposterior axis. Both excess and deficiency of RA can affect morphogenesis, including failures of neural tube closure. METHODS: We chose to investigate 5 genes involved in the metabolism or synthesis of RA, ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2, for their role in the development of human neural tube defects, such as spina bifida. RESULTS: An association analysis using both allelic and genotypic single-locus tests revealed a significant association between the risk for spina bifida and 3 polymorphisms in the gene ALDH1A2; however, we found no evidence of a significant multilocus association. CONCLUSIONS: These results may suggest that polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele in humans.

Full Text

Duke Authors

Cited Authors

  • Deak, KL; Dickerson, ME; Linney, E; Enterline, DS; George, TM; Melvin, EC; Graham, FL; Siegel, DG; Hammock, P; Mehltretter, L; Bassuk, AG; Kessler, JA; Gilbert, JR; Speer, MC; NTD Collaborative Group,

Published Date

  • November 2005

Published In

Volume / Issue

  • 73 / 11

Start / End Page

  • 868 - 875

PubMed ID

  • 16237707

Pubmed Central ID

  • 16237707

International Standard Serial Number (ISSN)

  • 1542-0752

Digital Object Identifier (DOI)

  • 10.1002/bdra.20183

Language

  • eng

Conference Location

  • United States