Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy.
Journal Article (Journal Article)
We describe a 20-year-old patient with cystic fibrosis who developed acute nonoliguric renal failure associated with inhaled tobramycin. Clinical evaluation and renal biopsy findings were consistent with aminoglycoside-induced changes. Renal failure due to inhaled aminoglycosides has not been previously reported. The incidence may rise, however, with the increased use of this treatment modality. Measurable tobramycin levels due to inhalational therapy with conventional dosing in the reported patient indicate that the drug can be systemically absorbed, and renal tubular toxicity may occur.
Full Text
Duke Authors
Cited Authors
- Hoffmann, IM; Rubin, BK; Iskandar, SS; Schechter, MS; Nagaraj, SK; Bitzan, MM
Published Date
- November 2002
Published In
Volume / Issue
- 34 / 5
Start / End Page
- 375 - 377
PubMed ID
- 12357482
International Standard Serial Number (ISSN)
- 8755-6863
Digital Object Identifier (DOI)
- 10.1002/ppul.10185
Language
- eng
Conference Location
- United States