Neurocognitive impairment in children and adolescents with systemic lupus erythematosus.

Journal Article (Journal Article;Review)

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, in which neuropsychiatric manifestations are a common cause of significant morbidity. The American College of Rheumatology has identified 19 distinct neuropsychiatric syndromes associated with SLE, although the 1982 American College of Rheumatology classification criteria for SLE recognize only two: seizures and psychosis. Neurocognitive impairment (NCI) is one of the most common and clinically challenging manifestations of SLE, but its pathophysiology remains poorly understood. This Review examines the epidemiology and pathophysiology of NCI in children and adolescents with SLE, as well as the diagnostic and therapeutic approaches that are available for these patients. As few published studies specifically address NCI in pediatric SLE, new directions for research are also discussed.

Full Text

Duke Authors

Cited Authors

  • Levy, DM; Ardoin, SP; Schanberg, LE

Published Date

  • February 2009

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 106 - 114

PubMed ID

  • 19182817

Pubmed Central ID

  • PMC2918878

Electronic International Standard Serial Number (EISSN)

  • 1745-8390

Digital Object Identifier (DOI)

  • 10.1038/ncprheum0988


  • eng

Conference Location

  • United States