Imaging genetics of brain longevity and mental wellness: the next frontier?

Published

Journal Article (Review)

The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great interest in applying these technologies not only to diagnose and prevent disease, but also to enhance brain longevity and mental wellness. Nearly two-thirds of the approximately 30,000 genes in the human genome are related to brain function, and up to half of the variance in age-related changes in cognition, brain volume, and neuronal function appears to be genetically determined. Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice.

Full Text

Duke Authors

Cited Authors

  • Petrella, JR; Mattay, VS; Doraiswamy, PM

Published Date

  • January 2008

Published In

Volume / Issue

  • 246 / 1

Start / End Page

  • 20 - 32

PubMed ID

  • 18096526

Pubmed Central ID

  • 18096526

Electronic International Standard Serial Number (EISSN)

  • 1527-1315

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiol.2461061994

Language

  • eng