Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study.

Journal Article (Journal Article)

OBJECTIVE: Functional deactivation of the posteromedial cortex (PMC) seems to be a physiologic process underlying normal memory. The authors examined whether older subjects with subsyndromal depressive symptoms show impaired PMC deactivation. DESIGN: Subjects underwent 4T functional magnetic resonance imaging scan while performing a novel and familiar face-name associative encoding task. The Beck-II Depression Inventory (BDI) was used to self-rate depression symptoms. A novel-minus-familiar encoding contrast was built into a simple regression model showing brain activation magnitudes that covaried with BDI score. A region-of-interest mask was applied to isolate the PMC and other midline structures of the default-mode network. SETTING: The study was conducted at a university-based medical center. PARTICIPANTS: Participants included 62 nondemented subjects aged 55-85, with and without mild memory deficits. BDI scores ranged from 0 to 17. RESULTS: Analysis revealed a distinct PMC cluster confined to the dorsal posterior cingulate cortex (BA 31) whose activity correlated significantly with BDI score. A multiple regression model further showed that BDI score, as well as a history of depression and current use of antidepressants, had a significant effect on cluster variance, while age, education, gender, and mini-mental state exam scores did not. CONCLUSIONS: Our findings raise the hypothesis that subsyndromal depressive symptoms in late life may impair physiological PMC deactivation in the dorsal posterior cingulate cortex. A prospective study of a full spectrum of depressed patients may be warranted.

Full Text

Duke Authors

Cited Authors

  • Woo, SL; Prince, SE; Petrella, JR; Hellegers, C; Doraiswamy, PM

Published Date

  • January 2009

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 24 - 29

PubMed ID

  • 18790875

Pubmed Central ID

  • PMC2614878

Electronic International Standard Serial Number (EISSN)

  • 1545-7214

Digital Object Identifier (DOI)

  • 10.1097/JGP.0b013e318180056a


  • eng

Conference Location

  • England