Sinonasal carcinoma after irradiation for medulloblastoma in nevoid basal cell carcinoma syndrome.

Journal Article (Journal Article)

BACKGROUND: Nevoid basal cell carcinoma syndrome (NBCCS) is associated with multiple basal cell carcinomas, odontogenic cysts, craniofacial anomalies, and childhood medulloblastomas. In addition, it has been associated with irradiation-induced neoplasms including, meningiomas, sarcomas, and gliomas. METHODS: We present a 19-year-old man with NBCCS who presented with a sinonasal carcinoma 17 years after receiving craniospinal irradiation for treatment of medulloblastoma. RESULTS: To our knowledge, this is the first report of a sinonasal tumor after irradiation in a patient with NBCCS. CONCLUSIONS: With this case, the authors examine the genotype of NBCCS patients and their propensity for radiation-induced tumors. In addition, the management of neoplasms in these tumor-sensitive patients is reviewed.

Full Text

Duke Authors

Cited Authors

  • Wallin, JL; Tanna, N; Misra, S; Puri, PK; Sadeghi, N

Published Date

  • 2007

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 360 - 362

PubMed ID

  • 17826543

International Standard Serial Number (ISSN)

  • 0196-0709

Digital Object Identifier (DOI)

  • 10.1016/j.amjoto.2006.10.006


  • eng

Conference Location

  • United States