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CD4/CD8 double negative pagetoid reticulosis: a case report and literature review.

Publication ,  Journal Article
Mourtzinos, N; Puri, PK; Wang, G; Liu, M-L
Published in: J Cutan Pathol
April 2010

Pagetoid reticulosis is an indolent primary cutaneous T-cell lymphoma. It typically presents as a solitary and slowly growing patch or plaque on the extremity, histologically characterized by an acanthotic epidermis infiltrated with atypical lymphocytes. Here, we present histological, immunophenotypical and molecular findings of a 29-year-old Jamaican man with bilateral wrist plaques. Histology showed marked acanthosis, hyperkeratosis and an intraepidermal infiltration consisting of large atypical lymphocytes. Immunohistochemical stains showed CD3 and CD5 positive T cells with significant loss of CD7, double negative CD4 and CD8 and strong positive CD30. Molecular analysis showed a monoclonal T-cell receptor (TCR) gamma gene rearrangement. Review of the literature confirms that the immunophenotype of pagetoid reticulosis is variable with decreasing frequency of CD8+ cytotoxic/suppressor T cell, CD4+ helper T cell and least commonly CD4/CD8 double negative phenotypes. Although CD4/CD8 double negative phenotype appears to be associated with higher proliferation index, it does not appear to confer prognostic significance.

Duke Scholars

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

April 2010

Volume

37

Issue

4

Start / End Page

491 / 496

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Skin Neoplasms
  • Pagetoid Reticulosis
  • Male
  • Immunophenotyping
  • Immunohistochemistry
  • Humans
  • Dermatology & Venereal Diseases
  • CD8-Positive T-Lymphocytes
  • CD4-Positive T-Lymphocytes
 

Citation

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Mourtzinos, N., Puri, P. K., Wang, G., & Liu, M.-L. (2010). CD4/CD8 double negative pagetoid reticulosis: a case report and literature review. J Cutan Pathol, 37(4), 491–496. https://doi.org/10.1111/j.1600-0560.2009.01323.x
Mourtzinos, Nikki, Puja K. Puri, Guanghua Wang, and Min-Ling Liu. “CD4/CD8 double negative pagetoid reticulosis: a case report and literature review.J Cutan Pathol 37, no. 4 (April 2010): 491–96. https://doi.org/10.1111/j.1600-0560.2009.01323.x.
Mourtzinos N, Puri PK, Wang G, Liu M-L. CD4/CD8 double negative pagetoid reticulosis: a case report and literature review. J Cutan Pathol. 2010 Apr;37(4):491–6.
Mourtzinos, Nikki, et al. “CD4/CD8 double negative pagetoid reticulosis: a case report and literature review.J Cutan Pathol, vol. 37, no. 4, Apr. 2010, pp. 491–96. Pubmed, doi:10.1111/j.1600-0560.2009.01323.x.
Mourtzinos N, Puri PK, Wang G, Liu M-L. CD4/CD8 double negative pagetoid reticulosis: a case report and literature review. J Cutan Pathol. 2010 Apr;37(4):491–496.
Journal cover image

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

April 2010

Volume

37

Issue

4

Start / End Page

491 / 496

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Skin Neoplasms
  • Pagetoid Reticulosis
  • Male
  • Immunophenotyping
  • Immunohistochemistry
  • Humans
  • Dermatology & Venereal Diseases
  • CD8-Positive T-Lymphocytes
  • CD4-Positive T-Lymphocytes