Bayesian semiparametric multiple shrinkage.
Journal Article (Journal Article)
High-dimensional and highly correlated data leading to non- or weakly identified effects are commonplace. Maximum likelihood will typically fail in such situations and a variety of shrinkage methods have been proposed. Standard techniques, such as ridge regression or the lasso, shrink estimates toward zero, with some approaches allowing coefficients to be selected out of the model by achieving a value of zero. When substantive information is available, estimates can be shrunk to nonnull values; however, such information may not be available. We propose a Bayesian semiparametric approach that allows shrinkage to multiple locations. Coefficients are given a mixture of heavy-tailed double exponential priors, with location and scale parameters assigned Dirichlet process hyperpriors to allow groups of coefficients to be shrunk toward the same, possibly nonzero, mean. Our approach favors sparse, but flexible, structure by shrinking toward a small number of random locations. The methods are illustrated using a study of genetic polymorphisms and Parkinson's disease.
Full Text
Duke Authors
Cited Authors
- Maclehose, RF; Dunson, DB
Published Date
- June 2010
Published In
Volume / Issue
- 66 / 2
Start / End Page
- 455 - 462
PubMed ID
- 19508244
Pubmed Central ID
- PMC3631538
Electronic International Standard Serial Number (EISSN)
- 1541-0420
International Standard Serial Number (ISSN)
- 0006-341X
Digital Object Identifier (DOI)
- 10.1111/j.1541-0420.2009.01275.x
Language
- eng