Living donor kidney transplant recipients and clinical trials: participation profiles and impact on post-transplant care.

Published

Journal Article

Many transplant physicians believe that transplant candidates who enroll in clinical trials may have better outcomes than those who do not enroll. We examined a 7-year cohort (1997-2003) of adult primary, non-HLA identical, living donor kidney transplant (LDKT) recipients to determine whether demographic characteristics predisposed to enrollment and whether participation affected posttransplant care intensity and/or allograft function. Overall, 146 of 512 (28.5%) LDKT recipients enrolled in clinical trials. LDKT recipients who were male and those who lived <100 miles from our transplant center were significantly more likely to participate. During the first post-transplant year, study patients (SPs) had more clinic visits (p < 0.0001) and more allograft biopsies (p = 0.024) compared to nonstudy patients (NSPs), but comparable numbers of hospital readmissions and allograft ultrasounds. SPs and NSPs did not differ in 1-year creatinine clearance, delta creatinine or rejection incidence. Overall graft and patient survival were comparable. We conclude that clinical trial participants were disproportionately male, had increased intensity of post-transplant care but comparable outcomes to nonparticipants.

Full Text

Cited Authors

  • Brennan, TV; Fuller, TF; Vincenti, F; Chan, S; Chang, CK; Bostrom, A; Zlatunich, JK; Tomlanovich, SJ; Feng, S

Published Date

  • October 2006

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • 2429 - 2435

PubMed ID

  • 16925565

Pubmed Central ID

  • 16925565

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2006.01504.x

Language

  • eng