Complex trait genetics of refractive error.

Journal Article (Journal Article;Review)

Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous disorders of the human eye and are ideal for genetic investigation. Moderate to severe refractive errors can predispose individuals to poor visual development, various types of glaucoma, misshapen corneal surfaces, premature cataracts, and loss of retinal integrity, which can lead to detachment. Knowledge of genetic mechanisms involved in refractive error susceptibility may allow treatment to prevent progression or to further examine gene-environment interactions. Early genetic predisposition detection for developing severe refractive errors may be useful for efficient and cost-effective screening program design. This review explores the genetic mechanisms associated with nonsyndromic refractive error development known to date.

Full Text

Duke Authors

Cited Authors

  • Young, TL; Metlapally, R; Shay, AE

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 125 / 1

Start / End Page

  • 38 - 48

PubMed ID

  • 17210850

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.125.1.38


  • eng

Conference Location

  • United States