Molecular genetics of human myopia: an update.

Journal Article

Myopia, or nearsightedness, is the most common human eye disorder in the world, and is a significant global public health concern. Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes of visual impairment worldwide. Severe or high-grade myopia is a leading cause of blindness because of its associated ocular morbidities of retinal detachment, macular choroidal degeneration, premature cataract, and glaucoma. Ample evidence documents the heritability of the non-syndromic forms of this condition, especially for high-grade myopia, commonly referred to as myopic spherical refractive power of 5 to 6 diopters or higher. Multiple high-grade myopia genetic loci have been identified, and confirmatory studies identifying high-grade and moderate myopia loci have also occurred. In general, myopia susceptibility genes are unknown with few association studies performed, and without confirmation in other research laboratories or testing of separate patient cohorts.

Full Text

Duke Authors

Cited Authors

  • Young, TL

Published Date

  • January 2009

Published In

Volume / Issue

  • 86 / 1

Start / End Page

  • E8 - E22

PubMed ID

  • 19104467

Pubmed Central ID

  • PMC3718050

Electronic International Standard Serial Number (EISSN)

  • 1538-9235

Digital Object Identifier (DOI)

  • 10.1097/OPX.0b013e3181940655


  • eng

Conference Location

  • United States