Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17.


Journal Article

Five loci that map to human chromosome 4 (HSA4) were selected to expand the bovine comparative linkage map. Loci included b-casein (CSN2), basic fibroblast growth factor (FGF2), immunoglobulin J chain (IGJ), interleukin 2 (IL2) and microsomal triglyceride transfer protein (MTTP). Polymorphisms for each locus were identified by either polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or single-strand conformational polymorphism (SSCP) analysis. The bovine genes for CSN2, IGJ and MTTP were mapped by linkage analysis to chromosome 6; FGF2 and IL2 mapped to chromosome 17. These data refine a position of chromosomal evolution to a small region between FGF2 and the previously mapped complement I factor (IF).

Full Text

Cited Authors

  • Fisher, SR; Beever, JE; Lewin, HA

Published Date

  • August 1997

Published In

Volume / Issue

  • 28 / 4

Start / End Page

  • 253 - 257

PubMed ID

  • 9345721

Pubmed Central ID

  • 9345721

Electronic International Standard Serial Number (EISSN)

  • 1365-2052

International Standard Serial Number (ISSN)

  • 0268-9146

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2052.1997.00131.x


  • eng