Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.

Journal Article (Journal Article)

BACKGROUND: Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor growth. It is synergistic with radiotherapy in gastrointestinal malignancies. Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma. METHODS: Two patients diagnosed with angiosarcoma of the nose were treated preoperatively with bevacizumab (5-10 mg/kg) and concurrent radiotherapy (50 Gy), followed by resection of the tumor bed. RESULTS: Both patients had a complete pathologic response with no residual disease. Neither has developed recurrence, with follow-up of 8.5 months and 2.1 years. CONCLUSIONS: The neoadjuvant combination of bevacizumab and radiation therapy is promising and should be further studied in the setting of vascular malignancies.

Full Text

Duke Authors

Cited Authors

  • Koontz, BF; Miles, EF; Rubio, MAD; Madden, JF; Fisher, SR; Scher, RL; Brizel, DM

Published Date

  • February 2008

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 262 - 266

PubMed ID

  • 17685450

International Standard Serial Number (ISSN)

  • 1043-3074

Digital Object Identifier (DOI)

  • 10.1002/hed.20674


  • eng

Conference Location

  • United States