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Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.

Publication ,  Journal Article
Laje, G; Allen, AS; Akula, N; Manji, H; John Rush, A; McMahon, FJ
Published in: Pharmacogenet Genomics
September 2009

OBJECTIVES: Suicidal ideation is an uncommon but worrisome symptom than can emerge during antidepressant treatment. We have described earlier the association between treatment-emergent suicidal ideation (TESI) and markers in genes encoding glutamate receptor subunits GRIK2 and GRIA3. The present genome-wide association study was conducted to identify additional genetic markers associated with TESI that may help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, and/or specialty care. METHODS: A clinically representative cohort of outpatients with nonpsychotic major depressive disorder enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated with citalopram under a standard protocol for up to 14 weeks. DNA samples from 90 White participants who developed TESI and a sex-matched and race-matched equal number of treated participants who denied any suicidal ideas were genotyped with 109 365 single nucleotide polymorphisms on the Illumina's Human-1 BeadChip. RESULTS: One marker was found to be associated with TESI in this sample at the experiment-wide adjusted P less than 0.05 level (marker rs11628713, allelic P = 6.2x10, odds ratio = 4.7, permutation P = 0.01). A second marker was associated at the experiment-wide adjusted P = 0.06 level (rs10903034, allelic P = 3.02x10, odds ratio = 2.7, permutation P = 0.06). These markers reside within the genes PAPLN and IL28RA, respectively. PAPLN encodes papilin, a protoglycan-like sulfated glycoprotein. IL28RA encodes an interleukin receptor. CONCLUSION: Together with our earlier report, these findings may shed light on the biological basis of TESI and may help identify patients at increased risk of this potentially serious adverse event.

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Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

September 2009

Volume

19

Issue

9

Start / End Page

666 / 674

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Suicide
  • Selective Serotonin Reuptake Inhibitors
  • Retrospective Studies
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Outpatients
 

Citation

APA
Chicago
ICMJE
MLA
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Laje, G., Allen, A. S., Akula, N., Manji, H., John Rush, A., & McMahon, F. J. (2009). Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Pharmacogenet Genomics, 19(9), 666–674. https://doi.org/10.1097/FPC.0b013e32832e4bcd
Laje, Gonzalo, Andrew S. Allen, Nirmala Akula, Husseini Manji, A. John Rush, and Francis J. McMahon. “Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.Pharmacogenet Genomics 19, no. 9 (September 2009): 666–74. https://doi.org/10.1097/FPC.0b013e32832e4bcd.
Laje G, Allen AS, Akula N, Manji H, John Rush A, McMahon FJ. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Pharmacogenet Genomics. 2009 Sep;19(9):666–74.
Laje, Gonzalo, et al. “Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.Pharmacogenet Genomics, vol. 19, no. 9, Sept. 2009, pp. 666–74. Pubmed, doi:10.1097/FPC.0b013e32832e4bcd.
Laje G, Allen AS, Akula N, Manji H, John Rush A, McMahon FJ. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Pharmacogenet Genomics. 2009 Sep;19(9):666–674.

Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

September 2009

Volume

19

Issue

9

Start / End Page

666 / 674

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Suicide
  • Selective Serotonin Reuptake Inhibitors
  • Retrospective Studies
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Outpatients