The effect of combined daunorubicin and triamcinolone acetonide treatment on a refined experimental model of proliferative vitreoretinopathy.

Published

Journal Article

Prior studies have shown that intravitreal daunorubicin (9-15 nmol) and triamcinolone acetonide (2 mg) are effective individually in preventing retinal detachment in experimental proliferative vitreoretinopathy. This report compares the efficacy of the combination of daunorubicin (15 nmol) and triamcinolone acetonide (2 mg) with that of daunorubicin alone in a refined experimental model of proliferative vitreoretinopathy. The degree of retinal detachment in each treatment group was graded, with the unequivocal absence or presence of retinal detachment used as an indicator of treatment success or failure. Both treatments (daunorubicin alone and in combination with triamcinolone acetonide) effectively prevented retinal detachment. However, there was no significant difference in the rate of retinal detachment between the two treatment groups. These results indicate that combination therapy with daunorubicin/triamcinolone is no more effective at preventing retinal detachment than daunorubicin alone.

Full Text

Duke Authors

Cited Authors

  • Chen, EP; Steinhorst, UH; Samsa, GP; Saloupis, PT; Hatchell, DL

Published Date

  • June 1992

Published In

Volume / Issue

  • 33 / 7

Start / End Page

  • 2160 - 2164

PubMed ID

  • 1607226

Pubmed Central ID

  • 1607226

International Standard Serial Number (ISSN)

  • 0146-0404

Language

  • eng

Conference Location

  • United States