COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.
Journal Article (Journal Article)
PURPOSE: Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets. METHODS: High-grade myopia was defined as
Full Text
Duke Authors
Cited Authors
- Metlapally, R; Li, Y-J; Tran-Viet, K-N; Abbott, D; Czaja, GR; Malecaze, F; Calvas, P; Mackey, D; Rosenberg, T; Paget, S; Zayats, T; Owen, MJ; Guggenheim, JA; Young, TL
Published Date
- September 2009
Published In
Volume / Issue
- 50 / 9
Start / End Page
- 4080 - 4086
PubMed ID
- 19387081
Pubmed Central ID
- PMC3936411
Electronic International Standard Serial Number (EISSN)
- 1552-5783
Digital Object Identifier (DOI)
- 10.1167/iovs.08-3346
Language
- eng
Conference Location
- United States