COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.
PURPOSE: Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets. METHODS: High-grade myopia was defined as
Metlapally, R; Li, Y-J; Tran-Viet, K-N; Abbott, D; Czaja, GR; Malecaze, F; Calvas, P; Mackey, D; Rosenberg, T; Paget, S; Zayats, T; Owen, MJ; Guggenheim, JA; Young, TL
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