COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.

Journal Article (Journal Article)

PURPOSE: Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets. METHODS: High-grade myopia was defined as

Full Text

Duke Authors

Cited Authors

  • Metlapally, R; Li, Y-J; Tran-Viet, K-N; Abbott, D; Czaja, GR; Malecaze, F; Calvas, P; Mackey, D; Rosenberg, T; Paget, S; Zayats, T; Owen, MJ; Guggenheim, JA; Young, TL

Published Date

  • September 2009

Published In

Volume / Issue

  • 50 / 9

Start / End Page

  • 4080 - 4086

PubMed ID

  • 19387081

Pubmed Central ID

  • PMC3936411

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.08-3346


  • eng

Conference Location

  • United States