Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study.

Journal Article (Clinical Trial;Journal Article)

Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE epsilon4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

Full Text

Duke Authors

Cited Authors

  • Fotuhi, M; Zandi, PP; Hayden, KM; Khachaturian, AS; Szekely, CA; Wengreen, H; Munger, RG; Norton, MC; Tschanz, JT; Lyketsos, CG; Breitner, JCS; Welsh-Bohmer, K

Published Date

  • May 2008

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 223 - 227

PubMed ID

  • 18631971

Pubmed Central ID

  • PMC2684982

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2008.01.004


  • eng

Conference Location

  • United States