The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.


Journal Article

Following infection of the host with a virus, the delicate balance between virus replication/spread and the immune response to the virus determines the outcome of infection, i.e., persistence versus elimination of the virus. It is unclear, however, what relative roles immunologic and virologic factors play during primary viral infection in determining the subsequent clinical outcome. By studying a cohort of subjects with primary HIV infection, it has been demonstrated that qualitative differences in the primary immune response to HIV, but not quantitative differences in the initial levels of viremia are associated with different clinical outcomes.

Full Text

Duke Authors

Cited Authors

  • Pantaleo, G; Demarest, JF; Schacker, T; Vaccarezza, M; Cohen, OJ; Daucher, M; Graziosi, C; Schnittman, SS; Quinn, TC; Shaw, GM; Perrin, L; Tambussi, G; Lazzarin, A; Sekaly, RP; Soudeyns, H; Corey, L; Fauci, AS

Published Date

  • January 7, 1997

Published In

Volume / Issue

  • 94 / 1

Start / End Page

  • 254 - 258

PubMed ID

  • 8990195

Pubmed Central ID

  • 8990195

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.94.1.254


  • eng

Conference Location

  • United States