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Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.

Publication ,  Journal Article
Graziosi, C; Pantaleo, G; Gantt, KR; Fortin, JP; Demarest, JF; Cohen, OJ; Sékaly, RP; Fauci, AS
Published in: Science
July 8, 1994

A switch from a T helper 1 (TH1) cytokine phenotype to a TH2 phenotype has been proposed as a critical element in the progression of human immunodeficiency virus (HIV) disease. Here, constitutive cytokine expression was analyzed in unfractionated and sorted cell populations isolated from peripheral blood and lymph nodes of HIV-infected individuals at different stages of disease. Expression of interleukin-2 (IL-2) and IL-4 was barely detectable (or undetectable) regardless of the stage of disease. CD8+ cells expressed large amounts of interferon gamma and IL-10, and the levels of these cytokines remained stably high throughout the course of infection. Furthermore, similar patterns of cytokine expression were observed after stimulation in vitro of purified CD4+ T cell populations obtained from HIV-infected individuals at different stages of disease. These results indicate that a switch from the TH1 to the TH2 cytokine phenotype does not occur during the progression of HIV disease.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

July 8, 1994

Volume

265

Issue

5169

Start / End Page

248 / 252

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocyte Subsets
  • Phenotype
  • Lymphocyte Activation
  • Lymph Nodes
  • Longitudinal Studies
  • Interleukins
  • Interleukin-4
  • Interleukin-2
  • Interleukin-10
 

Citation

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Graziosi, C., Pantaleo, G., Gantt, K. R., Fortin, J. P., Demarest, J. F., Cohen, O. J., … Fauci, A. S. (1994). Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science, 265(5169), 248–252. https://doi.org/10.1126/science.8023143
Graziosi, C., G. Pantaleo, K. R. Gantt, J. P. Fortin, J. F. Demarest, O. J. Cohen, R. P. Sékaly, and A. S. Fauci. “Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.Science 265, no. 5169 (July 8, 1994): 248–52. https://doi.org/10.1126/science.8023143.
Graziosi C, Pantaleo G, Gantt KR, Fortin JP, Demarest JF, Cohen OJ, et al. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science. 1994 Jul 8;265(5169):248–52.
Graziosi, C., et al. “Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.Science, vol. 265, no. 5169, July 1994, pp. 248–52. Pubmed, doi:10.1126/science.8023143.
Graziosi C, Pantaleo G, Gantt KR, Fortin JP, Demarest JF, Cohen OJ, Sékaly RP, Fauci AS. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science. 1994 Jul 8;265(5169):248–252.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

July 8, 1994

Volume

265

Issue

5169

Start / End Page

248 / 252

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocyte Subsets
  • Phenotype
  • Lymphocyte Activation
  • Lymph Nodes
  • Longitudinal Studies
  • Interleukins
  • Interleukin-4
  • Interleukin-2
  • Interleukin-10