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Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.

Publication ,  Journal Article
Pantaleo, G; Soudeyns, H; Demarest, JF; Vaccarezza, M; Graziosi, C; Paolucci, S; Daucher, MB; Cohen, OJ; Denis, F; Biddison, WE; Sekaly, RP; Fauci, AS
Published in: Eur J Immunol
December 1997

Down-regulation of the initial burst of viremia during primary human immunodeficiency virus (HIV) infection is thought to be mediated predominantly by HIV-specific CD8+ cytotoxic T lymphocytes (CTL). This response is associated with major perturbations in the T cell receptor (TCR) repertoire. To investigate the failure of the cellular immune response to adequately control viral spread and replication and to prevent establishment of HIV infection, changes in the TCR repertoire and in the distribution of virus-specific CTL between blood and lymph node were analyzed in three patients with primary infection. By the combined use of clonotype-specific polymerase chain reaction and analysis of the frequency of in vivo activated HIV-specific CTL, it was shown that HIV-specific CTL clones preferentially accumulated in blood as opposed to lymph node. Accumulation of HIV-specific CTL in blood occurred prior to effective down-regulation of virus replication in both blood and lymph node. These findings should provide new insights into how HIV, and possibly other viruses, elude the immune response of the host during primary infection.

Duke Scholars

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

December 1997

Volume

27

Issue

12

Start / End Page

3166 / 3173

Location

Germany

Related Subject Headings

  • Virus Replication
  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, alpha-beta
  • Lymph Nodes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Cell Movement
  • CD8-Positive T-Lymphocytes
 

Citation

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Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., … Fauci, A. S. (1997). Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. Eur J Immunol, 27(12), 3166–3173. https://doi.org/10.1002/eji.1830271213
Pantaleo, G., H. Soudeyns, J. F. Demarest, M. Vaccarezza, C. Graziosi, S. Paolucci, M. B. Daucher, et al. “Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.Eur J Immunol 27, no. 12 (December 1997): 3166–73. https://doi.org/10.1002/eji.1830271213.
Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, et al. Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. Eur J Immunol. 1997 Dec;27(12):3166–73.
Pantaleo, G., et al. “Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.Eur J Immunol, vol. 27, no. 12, Dec. 1997, pp. 3166–73. Pubmed, doi:10.1002/eji.1830271213.
Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, Daucher MB, Cohen OJ, Denis F, Biddison WE, Sekaly RP, Fauci AS. Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. Eur J Immunol. 1997 Dec;27(12):3166–3173.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

December 1997

Volume

27

Issue

12

Start / End Page

3166 / 3173

Location

Germany

Related Subject Headings

  • Virus Replication
  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, alpha-beta
  • Lymph Nodes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Cell Movement
  • CD8-Positive T-Lymphocytes