Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.

Journal Article (Journal Article)

An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+ T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+ cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

Full Text

Duke Authors

Cited Authors

  • Koenig, S; Conley, AJ; Brewah, YA; Jones, GM; Leath, S; Boots, LJ; Davey, V; Pantaleo, G; Demarest, JF; Carter, C

Published Date

  • April 1995

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 330 - 336

PubMed ID

  • 7585062

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm0495-330


  • eng

Conference Location

  • United States