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Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.

Publication ,  Journal Article
Koenig, S; Conley, AJ; Brewah, YA; Jones, GM; Leath, S; Boots, LJ; Davey, V; Pantaleo, G; Demarest, JF; Carter, C
Published in: Nat Med
April 1995

An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+ T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+ cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

April 1995

Volume

1

Issue

4

Start / End Page

330 / 336

Location

United States

Related Subject Headings

  • nef Gene Products, Human Immunodeficiency Virus
  • Virus Replication
  • T-Lymphocytes, Cytotoxic
  • Nucleic Acid Hybridization
  • Mutation
  • Molecular Sequence Data
  • Immunotherapy, Adoptive
  • Immunology
  • Humans
  • HIV-1
 

Citation

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Koenig, S., Conley, A. J., Brewah, Y. A., Jones, G. M., Leath, S., Boots, L. J., … Carter, C. (1995). Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat Med, 1(4), 330–336. https://doi.org/10.1038/nm0495-330
Koenig, S., A. J. Conley, Y. A. Brewah, G. M. Jones, S. Leath, L. J. Boots, V. Davey, G. Pantaleo, J. F. Demarest, and C. Carter. “Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.Nat Med 1, no. 4 (April 1995): 330–36. https://doi.org/10.1038/nm0495-330.
Koenig S, Conley AJ, Brewah YA, Jones GM, Leath S, Boots LJ, et al. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat Med. 1995 Apr;1(4):330–6.
Koenig, S., et al. “Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.Nat Med, vol. 1, no. 4, Apr. 1995, pp. 330–36. Pubmed, doi:10.1038/nm0495-330.
Koenig S, Conley AJ, Brewah YA, Jones GM, Leath S, Boots LJ, Davey V, Pantaleo G, Demarest JF, Carter C. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat Med. 1995 Apr;1(4):330–336.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

April 1995

Volume

1

Issue

4

Start / End Page

330 / 336

Location

United States

Related Subject Headings

  • nef Gene Products, Human Immunodeficiency Virus
  • Virus Replication
  • T-Lymphocytes, Cytotoxic
  • Nucleic Acid Hybridization
  • Mutation
  • Molecular Sequence Data
  • Immunotherapy, Adoptive
  • Immunology
  • Humans
  • HIV-1