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HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.

Publication ,  Journal Article
Pantaleo, G; Graziosi, C; Demarest, JF; Butini, L; Montroni, M; Fox, CH; Orenstein, JM; Kotler, DP; Fauci, AS
Published in: Nature
March 25, 1993

Primary infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

March 25, 1993

Volume

362

Issue

6418

Start / End Page

355 / 358

Location

England

Related Subject Headings

  • Polymerase Chain Reaction
  • Palatine Tonsil
  • Microscopy, Electron
  • Male
  • Lymphoid Tissue
  • Lymphocytes
  • Lymph Nodes
  • Inclusion Bodies, Viral
  • In Situ Hybridization
  • Humans
 

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Pantaleo, G., Graziosi, C., Demarest, J. F., Butini, L., Montroni, M., Fox, C. H., … Fauci, A. S. (1993). HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature, 362(6418), 355–358. https://doi.org/10.1038/362355a0
Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. “HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.Nature 362, no. 6418 (March 25, 1993): 355–58. https://doi.org/10.1038/362355a0.
Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature. 1993 Mar 25;362(6418):355–8.
Pantaleo, G., et al. “HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.Nature, vol. 362, no. 6418, Mar. 1993, pp. 355–58. Pubmed, doi:10.1038/362355a0.
Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature. 1993 Mar 25;362(6418):355–358.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

March 25, 1993

Volume

362

Issue

6418

Start / End Page

355 / 358

Location

England

Related Subject Headings

  • Polymerase Chain Reaction
  • Palatine Tonsil
  • Microscopy, Electron
  • Male
  • Lymphoid Tissue
  • Lymphocytes
  • Lymph Nodes
  • Inclusion Bodies, Viral
  • In Situ Hybridization
  • Humans