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Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission.

Publication ,  Journal Article
Pantaleo, G; Demarest, JF; Vaccarezza, M; Graziosi, C; Bansal, GP; Koenig, S; Fauci, AS
Published in: Eur J Immunol
January 1995

The present study was undertaken to compare the effects of a type-specific (HIV-1 MN) anti-V3 antibody on in vitro human immunodeficiency virus (HIV) infection of peripheral blood mononuclear cells in systems of cell-free versus cell-to-cell transmission of virus. Anti-V3 antibody completely prevented HIV-1 infection when cell-free virus was the sole mechanism of infection. A significant reduction of the neutralizing activity of the anti-V3 antibody was observed when infectivity was dependent on both cell-free and cell-to-cell mechanisms of infection. Furthermore, when cell-to-cell transfer of virions was the primary mechanism of HIV-1 infection, inhibition of HIV-1 infection was not observed. Therefore, a potent neutralizing antibody with a single epitope specificity failed to effectively control dissemination of a persistent HIV-1 infection in a system characterized predominantly by cell-to-cell transfer of virus.

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Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

January 1995

Volume

25

Issue

1

Start / End Page

226 / 231

Location

Germany

Related Subject Headings

  • Polymerase Chain Reaction
  • Peptide Fragments
  • Neutralization Tests
  • Molecular Sequence Data
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
 

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Pantaleo, G., Demarest, J. F., Vaccarezza, M., Graziosi, C., Bansal, G. P., Koenig, S., & Fauci, A. S. (1995). Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission. Eur J Immunol, 25(1), 226–231. https://doi.org/10.1002/eji.1830250137
Pantaleo, G., J. F. Demarest, M. Vaccarezza, C. Graziosi, G. P. Bansal, S. Koenig, and A. S. Fauci. “Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission.Eur J Immunol 25, no. 1 (January 1995): 226–31. https://doi.org/10.1002/eji.1830250137.
Pantaleo G, Demarest JF, Vaccarezza M, Graziosi C, Bansal GP, Koenig S, et al. Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission. Eur J Immunol. 1995 Jan;25(1):226–31.
Pantaleo, G., et al. “Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission.Eur J Immunol, vol. 25, no. 1, Jan. 1995, pp. 226–31. Pubmed, doi:10.1002/eji.1830250137.
Pantaleo G, Demarest JF, Vaccarezza M, Graziosi C, Bansal GP, Koenig S, Fauci AS. Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission. Eur J Immunol. 1995 Jan;25(1):226–231.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

January 1995

Volume

25

Issue

1

Start / End Page

226 / 231

Location

Germany

Related Subject Headings

  • Polymerase Chain Reaction
  • Peptide Fragments
  • Neutralization Tests
  • Molecular Sequence Data
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies