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Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection.

Publication ,  Journal Article
Pantaleo, G; Graziosi, C; Demarest, JF; Cohen, OJ; Vaccarezza, M; Gantt, K; Muro-Cacho, C; Fauci, AS
Published in: Immunol Rev
August 1994

The pathogenic mechanisms of HIV disease are multifactorial and multi-phasic. The common denominator of the disease is the profound immunosuppression that occurs in the vast majority of infected patients. Studies in lymphoid tissues in HIV disease have provided considerable insight into the pathogenic processes involved from the earliest phases of infection through the advanced stages. Following primary infection, virus is disseminated throughout the body and seeds the lymphoid tissue where its replication is only incompletely suppressed and where a reservoir of virus is established. Extracellular virus is trapped within the FDC of the lymph node germinal centers and serves as a source of infection for cells which reside in or migrate through the lymph node throughout the course of infection even during the early and often prolonged asymptomatic period. Eventually, the architecture of the lymphoid tissue is destroyed, compounding the immune dysfunction that results from the depletion of CD4+ T cells. In this regard, the lymphoid tissue of LTNPs is relatively intact and viral burden and replication is considerably lower in the peripheral blood and lymph node mono-nuclear cells of LTNPs than in individuals whose disease progresses. Cytokines probably play a major role in the modulation of HIV expression in the milieu of the lymphoid tissue. Further understanding of the pathogenic mechanisms operative in the lymphoid tissues of HIV-infected individuals will have important implications in the design of therapeutic strategies involving both antiretroviral and immunomodulatory approaches.

Duke Scholars

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

August 1994

Volume

140

Start / End Page

105 / 130

Location

England

Related Subject Headings

  • Virus Replication
  • Lymphoid Tissue
  • Lymph Nodes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Progression
  • Cytokines
  • CD4-Positive T-Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
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Pantaleo, G., Graziosi, C., Demarest, J. F., Cohen, O. J., Vaccarezza, M., Gantt, K., … Fauci, A. S. (1994). Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev, 140, 105–130. https://doi.org/10.1111/j.1600-065x.1994.tb00867.x
Pantaleo, G., C. Graziosi, J. F. Demarest, O. J. Cohen, M. Vaccarezza, K. Gantt, C. Muro-Cacho, and A. S. Fauci. “Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection.Immunol Rev 140 (August 1994): 105–30. https://doi.org/10.1111/j.1600-065x.1994.tb00867.x.
Pantaleo G, Graziosi C, Demarest JF, Cohen OJ, Vaccarezza M, Gantt K, et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev. 1994 Aug;140:105–30.
Pantaleo, G., et al. “Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection.Immunol Rev, vol. 140, Aug. 1994, pp. 105–30. Pubmed, doi:10.1111/j.1600-065x.1994.tb00867.x.
Pantaleo G, Graziosi C, Demarest JF, Cohen OJ, Vaccarezza M, Gantt K, Muro-Cacho C, Fauci AS. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev. 1994 Aug;140:105–130.

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

August 1994

Volume

140

Start / End Page

105 / 130

Location

England

Related Subject Headings

  • Virus Replication
  • Lymphoid Tissue
  • Lymph Nodes
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Progression
  • Cytokines
  • CD4-Positive T-Lymphocytes