Sequence signatures of a recent chromosomal rearrangement in Drosophila mojavensis.

Published

Journal Article

The X-chromosome inversion, Xe, distinguishes Drosophila mojavensis and D. arizonae. Earlier work mapped the breakpoints of this inversion to large intervals and provided hypotheses for the locations of the breakpoints within 3000-bp intergenic regions on the D. mojavensis genome sequence assembly. Here, we sequenced these regions directly in the putatively ancestral D. arizonae X-chromosome. We find that the two inversion breakpoints are near an inverted gene duplication and a common repetitive element, respectively, and these features were likely present in the non-inverted ancestral chromosome on the D. mojavensis lineage. Contrary to an earlier hypothesis, the inverted gene duplication appears to predate the inversion. We find no sequence similarity between the breakpoint regions in the D. mojavensis ancestor, excluding an ectopic-exchange model of chromosome rearrangements. We also found no evidence that staggered single-strand breaks caused the inversion. We suggest these features may have contributed to the chromosomal breakages resulting in this inversion.

Full Text

Duke Authors

Cited Authors

  • Runcie, DE; Noor, MAF

Published Date

  • May 2009

Published In

Volume / Issue

  • 136 / 1

Start / End Page

  • 5 - 11

PubMed ID

  • 18661244

Pubmed Central ID

  • 18661244

Electronic International Standard Serial Number (EISSN)

  • 1573-6857

International Standard Serial Number (ISSN)

  • 0016-6707

Digital Object Identifier (DOI)

  • 10.1007/s10709-008-9296-0

Language

  • eng