Molecular evolution of a Drosophila homolog of human BRCA2.

Journal Article (Journal Article)

The human cancer susceptibility gene, BRCA2, functions in double-strand break repair by homologous recombination, and it appears to function via interaction of a repetitive region ("BRC repeats") with RAD-51. A putatively simpler homolog, dmbrca2, was identified in Drosophila melanogaster recently and also affects mitotic and meiotic double-strand break repair. In this study, we examined patterns of repeat variation both within Drosophila pseudoobscura and among available Drosophila genome sequences. We identified extensive variation within and among closely related Drosophila species in BRC repeat number, to the extent that variation within this genus recapitulates the extent of variation found across the entire animal kingdom. We describe patterns of evolution across species by documenting recent repeat expansions (sometimes in tandem arrays) and homogenizations within available genome sequences. Overall, we have documented patterns and modes of evolution in a new model system of a gene which is important to human health.

Full Text

Duke Authors

Cited Authors

  • Bennett, SM; Noor, MAF

Published Date

  • November 2009

Published In

Volume / Issue

  • 137 / 2

Start / End Page

  • 213 - 219

PubMed ID

  • 19554456

Pubmed Central ID

  • PMC2756332

Electronic International Standard Serial Number (EISSN)

  • 1573-6857

International Standard Serial Number (ISSN)

  • 0016-6707

Digital Object Identifier (DOI)

  • 10.1007/s10709-009-9376-9


  • eng