Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation.


Journal Article

A(2A) receptors are a major class of G-protein-coupled receptors for adenosine. Highly expressed in the striatum, on the projection neurons giving rise to the striatopallidal or "indirect" pathway, they have been implicated in sleep, addiction, and other processes, yet their role in the control of striatal circuits and behavior remains unclear. Using established assays from the instrumental learning paradigm, we showed that mice with striatum-specific deletion of A(2A) receptors were selectively impaired in habit formation. After training that generated habitual lever pressing in wild-type controls, the performance of striatum-specific A(2A) knock-out mice remained goal directed, being highly sensitive to outcome devaluation and reversal of the action-outcome contingency. These data demonstrate a critical role for A(2A) receptors on striatopallidal medium spiny projection neurons in shaping behavior and decision making, providing the first instance of a selective alteration in instrumental learning after striatum-specific genetic manipulations.

Full Text

Duke Authors

Cited Authors

  • Yu, C; Gupta, J; Chen, J-F; Yin, HH

Published Date

  • December 2009

Published In

Volume / Issue

  • 29 / 48

Start / End Page

  • 15100 - 15103

PubMed ID

  • 19955361

Pubmed Central ID

  • 19955361

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.4215-09.2009


  • eng