A potential role for Elf-1 in CD4 promoter function.


Journal Article

The control of CD4 gene expression is believed to be linked directly to the signaling events that mediate T cell development and is directly dependent on the CD4 promoter. We have previously determined that this promoter contains four factor-binding sites important for its function. One of these sites, referred to as the P4 site, contains an Ets consensus recognition sequence. Using functional and biochemical analyses, we determine that Elf-1 binds to this site and specifically activates the CD4 promoter, indicating that Elf-1 is playing an important role in CD4 promoter function. In addition, a second nuclear factor binds to this region. Although there are consensus recognition sites for other factors, we demonstrate that none of these factors binds to the P4 site, nor do other known members of the Ets family. Thus, a novel transcription factor may bind to the CD4 promoter and help mediate its function.

Full Text

Duke Authors

Cited Authors

  • Sarafova, S; Siu, G

Published Date

  • June 4, 1999

Published In

Volume / Issue

  • 274 / 23

Start / End Page

  • 16126 - 16134

PubMed ID

  • 10347164

Pubmed Central ID

  • 10347164

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.274.23.16126


  • eng

Conference Location

  • United States